The laboratory's primary research interest is investigating the role of infectious agents in chronic diseases. Much of this work has revolved around
Helicobacter pylori infection as a cause of adenocarcinomas and lymphomas of the stomach. Other chronic disease-infection links that we have been investigating include the roles of infectious agents in atherosclerosis, and in cancers of the gastrointestinal tract. We continue to study diarrheal diseases in the U.S. and overseas and have developed a particular interest in gastric acid as a barrier to infection. We have also worked extensively on devising economically sound strategies for stomach cancer prevention and for vaccine development.
Additionally we are working with other groups inside and outside Stanford to develop teaching tools for clinical investigation and for use in public health in developing countries.